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The following lists area collection of the epigenetics resources in Alberta. Resources can include equipment, skills, personnel, companies, and other relevant resources. The list is a work in progress and will be updated continually. If you have a resource to add to the list please contact us.

List of facilities and infrastructure useful for epigenetics research.


Faciltiy Resources Equipment Personnel Institute Link
Flow Cytometry Facility Flow Cytometry TTUNE cytometers University of Calgary http://www.flowlab.ucalgary.ca/
Hotchkiss brain tumour initiating cell (BTIC) facility Brain tumour initiating University of Calgary http://www.hbi.ucalgary.ca/our-research/core-facilities
Flow Cytometry Facility Flow Cytometry BD LSR FORTESSA / FACSAria Dorothy Kratochwil-Otto University of Alberta http://flowcytometry.med.ualberta.ca/
The Applied Genomics Core Next Generation Sequencing / RNAseq Illumina MiSeq / Roche 454 Jr Dr. Andrew L. Mason University of Alberta http://tagc.med.ualberta.ca/
The Applied Genomics Core DNA Extraction and Quantification Qiagen AIQxcel / Agilent Bioanalyzer 2100 Dr. Andrew L. Mason University of Alberta http://tagc.med.ualberta.ca/
The Applied Genomics Core RT-PCR 7900HT Fast Real-Time PCR System Dr. Andrew L. Mason University of Alberta http://tagc.med.ualberta.ca/
Southern Alberta Mass Spectrometry (SAMS) Mass Spectrometry MS, LC/MS, SILAC, MALDI-TOF Dr. David Schriemer University of Calgary http://sams.ucalgary.ca/
RNAi Core (Li Ka Shing Institute of Virology) siRNA High-Throughput Genome-Wide Screening Facility Operetta High Content Imaging System / EnVision Multilabel Plate Reader / LI-COR Aerius Plate Reader / Mastercycler ep realplex Dr. Edan Foley University of Alberta https://sites.google.com/a/ualberta.ca/rnai/
Clara Christie Centre for Mouse Genomics Transgenic Mouse Dr. Frank Jirik University of Calgary http://www.ucalgary.ca/mousegenomics/
RNA Research and Training Institute Protein and RNA Purification Dr. Hans-Joachim Wieden University of Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA Research and Training Institute Molecular dynamics simulations Dr. Hans-Joachim Wieden University of Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA Research and Training Institute Enzyme Kinetics Dr. Hans-Joachim Wieden University of Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA Research and Training Institute RNA structure probing Dr. Hans-Joachim Wieden University of Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA Research and Training Institute In vitro transcription and protein synthesis Dr. Hans-Joachim Wieden University of Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Southern Alberta Group for Epigenetic Studies (SAGES) Sequencing (Bisulfide, Genome de novo, resequencing, metagenomic, mRNA, and ncRNA), Genome Analyser Iix Dr. Igor Kovalchuk University of Lethbridge http://people.uleth.ca/~igor.kovalchuk/index.html
Southern Alberta Group for Epigenetic Studies (SAGES) Chromatin Immunoprecipitation (ChIP)-seq Genome Analyser Iix Dr. Igor Kovalchuk University of Alberta http://people.uleth.ca/~igor.kovalchuk/index.html
Southern Alberta Group for Epigenetic Studies (SAGES) Epigenetics Arrays iScan (Illumina) Dr. Igor Kovalchuk University of Alberta http://likashingvirology.med.ualberta.ca/technology-platfroms/rnai-screening-facility/
SACRI Antibody Services Antibody Services Dr. Karl Riabowol University of Calgary http://www.ucalgary.ca/antibody/index.htm
Microscopy and Imaging Facility (MIF) Microscopy and Imaging Transmission Electron Microscopy, Scanning Electron Microscopy), Advanced Light Microscopy, Atomic Force Microscopy, and Single Cell Force Spectroscopy Dr. Matthias Amrein University of Calgary http://www.ucalgary.ca/mif/
ACHRI Genomics facility Bioinformatics Support Dr. Paul Gordon University of Calgary http://research4kids.ucalgary.ca/genomics/bioinformatics
ACHRI Genomics facility Next Generation Sequencing / RNAseq Ion Torrent PGM Dr. Richard T. Pon University of Calgary http://research4kids.ucalgary.ca/genomics
ACHRI Genomics facility Chromatin Immunoprecipitation (ChIP)-seq Life Technologies 5500xl Dr. Richard T. Pon University of Calgary http://research4kids.ucalgary.ca/genomics
ACHRI Genomics facility DNA Quantification Agilent TapeStation Dr. Richard T. Pon University of Calgary http://research4kids.ucalgary.ca/genomics
ACHRI Genomics facility Whole genome, exome and transcriptome sequencing Illumina NextSeq 500 Dr. Richard T. Pon University of Calgary http://research4kids.ucalgary.ca/genomics
University Core DNA Services DNA Synthesis Dr. Richard T. Pon University of Calgary http://www.ucalgary.ca/dnalab/
Cell Imaging Centre Microscopy and Imaging Transmission and Scanning electron microscopes, confocal microscopes and a super resolution microscope Dr. Stephen Ogg University of Alberta http://microscopy.med.ualberta.ca/
Clara Christie Centre for Mouse Genomics ES cell mutagenesis/transgenesis Dr. Derrick Rancourt University of Calgary http://www.ucalgary.ca/mousegenomics/
SACRI Microarray and Genomics Facility Microarray Affymetrix Xiuling Wang University of Calgary https://www.ucalgary.ca/microarraylab/

List of methodologies and expertise possessed by network members.

Methodology or Expertise Personnel Organization Location Link
Sequencing (Bisulfide, Genome de novo, resequencing, metagenomic, mRNA, and ncRNA) Igor Kovalchuk University of Lethbridge Lethbridge http://people.uleth.ca/~igor.kovalchuk/index.html
Chromatin Immunoprecipitation (ChIP)-seq Igor Kovalchuk University of Lethbridge Lethbridge http://people.uleth.ca/~igor.kovalchuk/index.html
High resolution immunofluorescence microscopy Aaron Goodarzi University of Calgary Calgary http://ucalgary.ca/bmb/profiles/dr-aaron-goodarzi
Human Cell-based assays Roy Golsteyn University of Lethbridge Lethbridge http://people.uleth.ca/~roy.golsteyn/
Genome-wide screening Tom Hobman University of Alberta Edmonton http://www.cellbiology.ualberta.ca/en/FacultyMembers/TomHobman.aspx
Super-resolution microscopy Tom Hobman University of Alberta Edmonton http://www.cellbiology.ualberta.ca/en/FacultyMembers/TomHobman.aspx
Antibody generation, validation and use Karl Riabowol University of Calgary Calgary http://www.ucalgary.ca/riabowol_lab/
Subcellular fractionation Karl Riabowol University of Calgary Calgary http://www.ucalgary.ca/riabowol_lab/
High level biocontainment for study of pathogenic viruses Tom Hobman University of Alberta Edmonton http://www.cellbiology.ualberta.ca/en/FacultyMembers/TomHobman.aspx
RNA Purification Ute Kothe RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA in vitro Transcription Ute Kothe RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Protein Purification Ute Kothe RNA Research and Training Institute Lethbridge เกมยิงปลาตายไวhttp://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
S. cerevisiae (Baker’s Yeast) Model System Ute Kothe RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Single Cell Sequencing (of cancer progression) Andrew Mason The Applied Genomics Core Edmonton http://tagc.med.ualberta.ca/
Digital PCR Lynne-Marie Postovit University of Alberta Edmonton http://oncology.med.ualberta.ca/AboutUs/FacultyMembers/Pages/ExperimentalOncology.aspx?P=145
Bisulfite Sequencing Lynne-Marie Postovit University of Alberta Edmonton http://oncology.med.ualberta.ca/AboutUs/FacultyMembers/Pages/ExperimentalOncology.aspx?P=145
Chromatin Immunoprecipitation(ChIP)-seq/PCR for Histone Modifications Lynne-Marie Postovit University of Alberta Edmonton http://oncology.med.ualberta.ca/AboutUs/FacultyMembers/Pages/ExperimentalOncology.aspx?P=145
Chromatin Fractionation Luis Schang University of Alberta Edmonton http://biochem.med.ualberta.ca/Research/faculty/Professors/Pages/Schang.aspx
ChIP (Chromatin Immunoprecipitation) Michael Schultz University of Alberta Edmonton http://www2.biochem.ualberta.ca/SchultzLab/index-1.html
In Vitro Reconstitution of Complex Biochemical Activities Michael Schultz University of Alberta Edmonton http://www2.biochem.ualberta.ca/SchultzLab/index-1.html
Discovery Using Budding Yeast as a Model Organism Michael Schultz University of Alberta Edmonton http://www2.biochem.ualberta.ca/SchultzLab/index-1.html
Formaldehyde-assisted Isolation of Regulatory Elements (FAIRE) Carol Schuurmans University of Calgary Calgary http://research4kids.ucalgary.ca/members/schuurmans_full
ChIP (Chromatin Immunoprecipitation) Carol Schuurmans University of Calgary Calgary http://research4kids.ucalgary.ca/members/schuurmans_full
Bisulfite sequencing Carol Schuurmans University of Calgary Calgary http://research4kids.ucalgary.ca/members/schuurmans_full
Chromatin Immunoprecipitation (ChIP)-seq Allan Underhill University of Alberta Edmonton http://www.oncology.med.ualberta.ca/aboutus/facultymembers/pages/experimentaloncology.aspx?p=1#sthash.atgK7Gu2.dpuf
RNA-seq Allan Underhill University of Alberta Edmonton http://www.oncology.med.ualberta.ca/aboutus/facultymembers/pages/experimentaloncology.aspx?p=1#sthash.atgK7Gu2.dpuf
Formaldehyde-assisted Isolation of Regulatory Elements (FAIRE)-seq Allan Underhill University of Alberta Edmonton http://www.oncology.med.ualberta.ca/aboutus/facultymembers/pages/experimentaloncology.aspx?p=1#sthash.atgK7Gu2.dpuf
Motif Discovery Allan Underhill University of Alberta Edmonton เกมยิงปลาตายไวhttp://www.oncology.med.ualberta.ca/aboutus/facultymembers/pages/experimentaloncology.aspx?p=1#sthash.atgK7Gu2.dpuf
Protein and RNA Purification Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Molecular dynamics simulations Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Enzyme Kinetics Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
RNA structure probing Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
In vitro transcription Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
In vitro protein synthesis Hans-Joachim Wieden RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Drug discovery Roy Golsteyn University of Lethbridge Lethbridge http://people.uleth.ca/~roy.golsteyn/
Gene amplification and copy number variation Randal N Johnston University of Calgary Calgary http://ucalgary.ca/bmb/profiles/dr-randal-n-johnston
Regulation of gene expression Randal N Johnston University of Calgary Calgary http://ucalgary.ca/bmb/profiles/dr-randal-n-johnston
Modulation of chromatin configuration Randal N Johnston University of Calgary Calgary http://ucalgary.ca/bmb/profiles/dr-randal-n-johnston
RNA-protein Interaction Ute Kothe RNA Research and Training Institute Lethbridge http://www.uleth.ca/artsci/biochemistry/alberta-rna-research-and-training-institute-arrti
Use of Blocking Agents and Activators of DNA Methylation to Alter Behavior Kenneth D. Lukowiak University of Calgary Calgary https://www.ucalgary.ca/pp/profiles/kenneth-d-lukowiak
Chromatin Dynamics Luis Schang University of Alberta Edmonton http://biochem.med.ualberta.ca/Research/faculty/Professors/Pages/Schang.aspx
Viral Chromatin Luis Schang University of Alberta Edmonton http://biochem.med.ualberta.ca/Research/faculty/Professors/Pages/Schang.aspx
Analysis of the relationship between epigenetic, behavioural, and neuroanatomical effects of experiences. Bryan Kolb Canadian Centre for Behavioural Neuroscience Lethbridge เกมยิงปลาตายไวhttp://www.uleth.ca/artsci/neuroscience/dr-bryan-e-kolb

List of companies conducting or applying epigenetics research in Alberta.

Company Services Contact in Alberta Contact Phone Contact Email Website
Resverlogix Corp.  Resverlogix Corp. (TSX: RVX) is a clinical stage cardiovascular company with an epigenetic platform technology that modulates protein production. Resverlogix is developing RVX-208, a first-in-class BET bromodomain inhibitor molecule for the treatment of atherosclerosis. Donald McCaffrey 1.403.254.9252 info@resverlogix.com http://www.resverlogix.com
Zenith Epigenetics Corp. Zenith Epigenetics Corp. is a biotechnology company with a broad and deep drug discovery platform in the area of epigenetics, developing orally active, small molecules that are selective for binding and inhibition of BET bromodomains. Zenith’s lead product is a pan selective BET inhibitor being developed for hematological malignancies and solid tumors. Donald McCaffrey 1.587.390.7865 info@zenithepigenetics.com http://www.zenithepigenetics.com
Plantbiosis PlantBiosis offers full scale plant transformation service and nucleotide deep sequencing service. Igor Kovalchuk 1.403.325.2579 igor.kovalchuk@uleth.ca http://www.plantbiosis.com
Canada Cancer and Aging Research Laboratories Canada Cancer and Aging Research Laboratories (CCARL) is a research and development company offering a personalized approach to cancer treatment. Empowered by decades of knowledge on molecular signatures of various cancers, sex- and age-specificity of cancer response to treatment, molecular and biochemical characteristics of regulation of various pro- and anti-cancer pathways, CCARL has been able to generate a product that allows doctors to make case-by-case decisions as far as a patient’s treatment is concerned. Olga Kovalchuk 1.403.3292579 olga.kovalchuk@ccarl.ca http://www.ccarl.ca
ChemRoutes Corp. ChemRoutes Corp. is a private drug discovery technology provider operating at the interface of organic chemistry, chemical biology, drug discovery, and nanotechnology. They are developing a collection of 200,000 small molecules with epigenetic properties (writers/erasers) on proprietary and novel small molecule based scaffolds. Aubrey Mendonca 1.780.988.1223 aubrey@chemroutes.com http://www.chemroutes.com/

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