คาสิโนออนไลน์ฟรี _สล็อตฟรีเครดิต ถอนได้ _คาสิโนออนไลน์ ฟรีเงิน
- Understanding how epigenetic marks influence development and how to prevent epigenetic-related developmental diseases.
- Investigating how the epigenetics changes that accumulate over time are related to aging and how to prevent aging-related diseases.
Stem cells (undifferentiated cells) have the potential to become any kind of cell or tissue type. The epigenetic profiles of stem cells change dynamically during development and control which genes in the cell are expressed. These epigenetic changes help transform undifferentiated stem cells into tissues and organs in a controlled manner. Understanding how these epigenetic profiles are established is important because errors in the epigenetic marks can lead to developmental diseases and impact reproductive success. Exposure to environmental factors can also impact developmental outcome through an organism’s epigenome. The change from stem cell to differentiated cell is typically a unidirectional change. Stem cells can turn into a multitude of other cell types, but these cell types typically do not revert back to stem cells. However, stem cells have great therapeutic potential. Learning how to control the epigenetic marks stopping an individual’s differentiated cells from acting as stem cells could help treat a wide range of diseases and conditions. Dr. Lynn-Marie Postovit from the University of Alberta is investigating the epigenetics of human pluripotent stem cell progression.
What makes our cells and bodies age is not, currently, well understood. It has been noted that as our cells age they undergo global changes in DNA methylation and other epigenetic changes. How these changes lead to cell aging and death could, eventually, lead to therapeutics to extend human lifespans. Projects by Dr. Karl Riabowol at the University of Calgary, and in the labs of Drs. Olga and Igor Kovalchuk’s and Dr. Bryan Kolb’s from the University of Lethbridge aim exactly at that – to understand the type of epigenetic changes that occur in aging tissues. Whereas Drs. Kovalchuk’s laboratories have recently found that aging is a tissue specific epigenetic process, the lab of Dr. Bryan Kolb, in collaboration with the lab of Dr. Olga Kovalchuk, is currently working on the analysis of brain-specific changes in response to chemotherapy of unrelated cancers.