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  • Understanding epigenetics of neurodegenerative diseases (Alzheimer’s, Fetal Alcohol Syndrome)
  • Role of epigenetics in strokes and in memory formation
  • Understanding epigenetic nature of transgenerational response to stress and its potential role in the development of behavioral and neurodegenerative diseases
  • Epigenetic approaches to treatment of neurodegenerative, psychiatric and behavioral diseases
Epigenetics has been shown to have an important role in both normal and abnormal brain function. Epigenetic marks are important in memory creation, long-term memory, and stress response, and involved in age-related memory decline, fetal alcohol syndrome disorder, chronic drug effects, and Parkinson’s disease.

Dr. Kenneth Lukowiak at the University of Calgary is investigating the role of epigenetics in memory formation using model organisms and Dr. Carol Schuurmans from the University of Calgary is studying the epigenetic regulation of cortical development. Members of the Canadian Centre for Behavioural Neuroscience (CCBN) (Drs. Bryan Kolb, Bruce McNaughton, Ian Wishaw, Robert Sutherland, Gerlinde Metz and Robert McDonald) have a long and productive record of collaborative research. The Centre is the indisputable leader in Canadian behavioural neuroscience and it has an exemplary international reputation for its contributions. Currently, CCBN researchers already collaborate with other researchers to investigate the role of epigenetics in a variety of areas: stroke, brain injury, age-related memory decline, fetal alcohol syndrome disorder, chronic drug effects, stress, long-term memory, and Parkinson’s disease, among others. These studies will provide an unprecedented view of the processing of information in neural networks and how these networks are shaped by experience as a result of epigenetic mechanisms.

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Alberta Government Genome Alberta University of Calgary University of Lethbridge University of Alberta