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Research on epigenetic mechanisms requires the basic knowledge of molecular and cell biology, as well as the availability of cutting-edge tools and specialized instrumentation for the analysis of epigenetic events at cellular and molecular levels. This work may develop new chemical entities that are designed to interact with the epigenetic machinery of the cell, thus creating the ability to control or revert various molecular processes disturbed in many genetic, epigenetic and metabolic diseases, including cancer, aging and others. In particular members of the RNA research and Training Institute (ARRTI) in Lethbridge, Dr. HJ Wieden and Dr. Ute Kothe, along with Dr. Tom Hobman from the University of Alberta and Dr. Don Fujita at the University of Calgary are investigating the role of RNAs and RNA modification in epigenetic control.
- Basic research on chromatin structure, non-coding RNAs, transcription, translation regulation, epigenome etc.
- Epigenetic regulation of viral reproduction
- Virus-induced chromatin remodeling and immune responses
Viral infection and replication can induce DNA methylation in both the host and on the viral DNA. This epigenetic modification can impact viral replication and integration into the host genome and lead to cancer development. Dr. Luis Schang and Dr. Tom Hobman, at the University of Alberta, are interested in how host virus interactions are controlled by epigenetic factors.