แอดไลน์รับเครดิตฟรี 50_ทดลองเล่นเกมยิงปลา_ให้ เงิน เล่น ฟรี
- Understanding how epigenetic changes can contribute to cancer development and how to use knowledge of epigenetics to develop cancer treatments
- Investigating what type of epigenetic changes occur in cancer cells or bystander cells exposed to radiation and chemical treatments
Epigenetic modifications, such as the silencing of tumor suppression genes or the activation of tumor causing genes (oncogenes), can lead to cancer. Additionally, in most cancers there are large scale modifications in the cancer cell’s epigenome that can play a role in cancer proliferation. Understanding what causes the epigenetic alterations and reversing them can help researchers prevent and treat cancer.
Alberta scientists have made important contributions to this research. Examples include the work of Dr. Olga Kovalchuk and her colleagues at the University of Lethbridge who have found profound epigenetic changes in cells responding to ionizing radiation and chemotherapy. Recent studies indicate that children of exposed parents have high mutation levels and a higher risk of cancers. The results of these studies have widespread implications on the current treatment regimes for cancer and the regulations regarding exposure to radiation. The work of Dr. Roy Golsteyn from the University of Lethbridge shows that certain chemicals disrupt cancer cells. His group is analyzing epigenetic factors contributing to this event. At the University of Alberta, Dr. Alan Underhill and Dr. Lynne-Marie Postovit study epigenetic control in cell differentiation and cancer and Dr. Michael Hendzel studies changes in chromosomal structure, a component of epigenetic response in developing cancer. At the University of Calgary, Dr. Susan Lees-Miller and Dr. Aaron Goodarzi study genome stability and mechanisms of DNA repair. Also at the University of Calgary Dr. Don Fujita investigates how RNA interference can inhibit oncogenes and Dr. Randal Johnston researches how Oncolytic Viruses can inhibit cancer progression.