คา สิ โน ออนไลน์ อันดับ 1_ทีเด็ดบอล_คาสิโนออนไลน์

University of Alberta

Gordon Chan Name: Gordon Chan
Position/Title: Associate Professor, Director Clinical Trials Unit, Director Glans Look Lung Cancer Database
Institution and affiliations: Experimental Oncology, Department of Oncology, University of Alberta, Cross Cancer Institute
Areas of Research: Health, Cancer, Mechanisms of Cell Cycle Control
Additional Information
Dr. Chan’s research is centered on the mechanism of cell cycle control and particularly the regulation of accurate chromosome segregation during mitosis. The mitotic checkpoint is a failsafe mechanism by which the cell prevents premature anaphase and ensures accurate chromosome segregation. The relevance of this line of basic research to cancer is established in the demonstrated importance of chromosome fidelity during cell division to carcinogenesis. Somatic mutations of mitotic checkpoint genes have been identified and postulated to be important for the chromosome instability phenotype in colorectal cancers. By investigating the molecular mechanism of the mitotic checkpoint, these genes can be better evaluated as potential cancer drug targets as well as contributing to the basic understanding of cancer.
Walter Dixon Name: Walter Dixon
Position/Title: Professor, Associate Vice-President/Research University of Alberta
Institution and affiliations: Agricultural, Food & Nutritional Science
Areas of Research: Agriculture, Livestock, Developmental Biology
Additional Information
Major Responsibilities/Research Interests

Research interests focus on gene expression as it relates to several fundamental cell biological processes including cell adhesion, and protein metabolism and secretion. In particular, current research involves the study of a family of four-pass membrane proteins implicated in a variety of cellular processes including adhesion and motility, platelet activation, growth factor signalling and cell proliferation. Members of this protein family are being studied in several normal and transformed eukaryotic cell systems. These studies utilize many recently developed techniques in protein biochemistry and molecular biology including cDNA cloning and expression, antibody screening of cDNA libraries, polymerase chain reaction (PCR) analysis and DNA sequencing. An understanding of the critical factors regulating these essential biological processes will have direct application to a variety of important issues in animal science including fertilization, embryo implantation and development, parasite infection and lactatio
Michael Dyck Name: Michael Dyck
Position/Title: Associate Professor, Member of AVRI Council, Lead investigator EmbryoGENE
Institution and affiliations: Agricultural, Food & Nutritional Science
Areas of Research: Agriculture, Livestock, and Gamete Physiology and Early Embryonic Development
Additional Information
Major Responsibilities/Research Interests

Main research interests are in gamete physiology and early embryonic development in swine. My work to date has involved gamete/embryo manipulation, the use of transgenic models to better understand various reproductive processes and the application of transgenesis to alter commercially desirable porcine characteristics. Research current focuses on the development and application of molecular techniques and advanced reproductive technologies, in collaboration with the pork production industry, to improve reproductive efficiency in swine.

I am also a lead researcher with the Pan-Canadian NSERC Strategic Research Network – EmbryoGENE. This collaborative research initiative is expected to provide us with the gene expression profile for pre-implantation porcine and bovine embryos. This information has the potential to dramatically alter our understanding of this critical period in mammalian development and appreciate how various factors may affect the embryos’ ability to survive, as well as the long-term impact that these factors may have on the embryos and resulting offspring that do survive. Within the Network I am currently the leader of a Research Theme to address the effects of reproductive technologies on embryo quality in swine.
Carolyn Fitzsimmons Name: Carolyn Fitzsimmons
Position/Title: Assistant/Adjunct Professor
Institution and affiliations: Agricultural, Food & Nutritional Science / Livestock Gentec
Areas of Research: Agriculture, Livestock, and Bovine Genetics and Gene Expression
Additional Information
Major Responsibilities/Research Interests

My interests lie in how biological systems influence the development of lean meat and fat tissues, specifically looking through the window of gene expression. Many new and exciting areas have now come to the forefront regarding the control of gene expression via dietary means (nutrigenomics), and the different individual responses to changes in diet (nutrigenetics). By utilizing changes in gene expression due to diet and/or other treatments, we can tease out a clearer understanding of how biological systems function and then apply this knowledge to practical situations, for example beef production. I am also interested permanent gene expression changes that can be programmed in the next generation due to nutrition and/or other factors affecting the parental generation (epigenetics).

Current & Past funding
2016 – PI of “gGreenBeefCow: Identifying and evaluating genomic and fecal microbiome markers for low methane emissions in beef cattle”. ($534,407)
2016 - Collaborator on “Development and application of functional genomic prediction for feed efficiency and carcass traits in beef cattle”. PI – Li C (AAFC) ($281,000)
2016 - Collaborator on “Genetic variations associated with feed efficiency and methane yield in beef cattle”. PI – Plastow G (UofA)($239,000)
2015 - Collaborator on “Can we improve cow and calf performance by increasing the amount of protein provided during late gestation?”. PI – Penner G (UofS)($ 444,782)
2014 - Collaborator on “Performance of RFI selected cattle under extensive cow/calf production systems”. PI – Bork E (UofA)($ 245,000)
2014 – PI of “Potential impacts of pre-natal nutrition and selection for residual feed intake (RFI) on bull reproductive development and fertility”. ($183,104)
2014 – Collaborator on “Genetics of the eating quality of high connective tissue beef”. PI – Bruce H (UofA)($ 260,658)
 
Daniel Graf Name: Daniel Graf
Position/Title: Associate Professor
Institution and affiliations: Faculty of Medicine & Dentistry
Areas of Research: Health, Development, Development of Orofacial Structures
Additional Information
The head is a very complicated structure and home to many important organs. Craniofacial tissues are affected in three out of four human congenital birth defects, but in most cases the underlying genetic variation remains unknown. We seek to understand how orofacial structures develop and what goes wrong in the case of malformations.

Orofacial structures develop through reciprocal interactions of neural crest and epithelial cells. Central to these interactions is the reiterated use of only a few conserved signaling networks, amongst them Bone Morphogenetic Protein signaling. Bone Morphogenetic Proteins (BMPs) are evolutionary highly conserved molecules that regulate the development of most embryonic tissues. These molecules are also involved in the homeostasis and repair of most adult tissues.

By altering BMP signalling in vivo we study their specific involvement during the development of orofacial structures, which helps us to understand how altered BMP signalling results in orofacial malformations. Untangling the molecular and cellular interactions will not only give us a better understanding of the developmental processes in question, but will also facilitate novel approaches for tissue repair.
Leluo Guan Name: Leluo Guan
Position/Title: Associate Professor
Institution and affiliations: Agricultural, Food & Nutritional Science, University of Alberta, Livestock Gentec
Areas of Research: Agriculture, Livestock, Bovine Transcriptome, Proteome, and Non-coding MicroRNAs
Additional Information
Major Responsibilities/Research Interests

  • Focuses on studying bovine “OMICS” and “MICROBES”
  • Elucidation of the molecular mechanisms of host-microbial interactions by characterization of bovine gut microbial ecology and its functions using metagenomics/metatranscriptomics approaches, and host gene expression using a functional genomics approach
  • Association between gut microbial ecology and feed efficiency, methane emission and gut immunity development in beef and dairy cattle
  • Study of the bovine transcriptome, proteome, and non-coding microRNAs and their roles in economically important traits
Michael Hendzel Name: Michael Hendzel
Position/Title: Professor
Institution and affiliations: Experimental Oncology, Department of Oncology / Cross Cancer Institute
Areas of Research: Health, Cancer, and Epigenetic Mechanisms Regulating Genome Structure and DNA Repair.
Additional Information
Structure, Dynamics, and Function in the Cell Nucleus
My laboratory is interested in the chromatin and nonchromatin structures of the cell nucleus, their dynamics, and their relationship to the major functions executed by the cell nucleus (transcription, mRNA processing, DNA replication, DNA repair). To study these processes, we employ a range of microscopy, biochemistry, and molecular biology techniques. 

Nuclear compartments and their function
It has been known for quite some time that the nucleus is not a homogeneous mass of DNA interspersed within a membrane-bound volume. Instead, both the genome and non-chromatin structures of the interphase nucleus are commonly seen to concentrate in discrete sites within the nucleus. These sites are generally referred to as nuclear compartments or nuclear bodies. While their composition and dynamics is increasingly understood, understanding their function has been more of a challenge. In order to get a better understanding of how compartmentalization regulates function, we are employing the formation of compartments around DNA double-strand breaks. These compartments are commonly referred to as ionizing radiation-induced foci despite being dependent on the type of damage (double-strand break) rather than the source of damage (ionizing radiation). For example, these compartments can also be induced using restriction endonucleases to introduce the double-strand break.

The Ataxia telangiectasia mutated (ATM) kinase is responsible for much of the kinase signaling that takes place in response to DNA double-strand breaks. The kinase is inactive in the absence of DNA damage and becomes active and autophosphorylates on serine 1981 when double-strand breaks are present. Following the induction of double-strand breaks, the ATM kinase enriches in the compartments that form around DNA double-strand breaks. We have found conditions where we are able to induce double-strand breaks and activate the ATM kinase but prevent the ATM kinase from enriching in these compartments. We know that, under these conditions, at least some of the ATM substrates are utilized. The vast number of characterized ATM substrates is allowing us to quantitatively determine the contribution of compartmentalization to the phosphorylation of ATM substrates and the execution of ATM functions.

Development of “colour” transmission electron microscopy
The contribution of light microscopy to our understanding of cell structure took a major leap forward when the appropriate antibody and nucleic acid probes and fluorescent labels became available. This allowed individual proteins and nucleic acids to be studied at the single cell level. Something similar is possible in transmission electron microscopy by using the “energy loss” spectrum instead of the wavelength spectrum of light. When the electron beam of the transmission electron microscope passes through the specimen, some of the electrons collide with inner shell electrons of the individual elements where the specimen element becomes ionized and the incident electron loses energy. The amount of energy lost depends on the element that the incident electron has ionized since the ionization energy for the electrons are defined. This type of transmission electron microscopy, termed electron spectroscopic imaging (ESI), is already a very useful technique for studying the cell nucleus. Both the phosphorus and nitrogen elements of the specimens generate strong signals that can be imaged. Because the phosphorus is so much more abundant in nucleic acid than nitrogen whereas proteins contain much less phosphorus relative to the nitrogen, the technique is particularly good at studying nucleic acids and looking at protein interactions with DNA or RNA. We are collaborating with the Wuest laboratory in the Department of Oncology, University of Alberta, to develop fluorinated and boronated probes, such as antibodies and modified nucleotides, in order to bring colour to the transmission electron microscope. We anticipate being able to visualize transcription directly in the transmission electron microscope, something that has only been possible in a model organism and information that is lacking with respect to structure-function relationships in the cell nucleus of mammals.

Other
We have additional research projects in the laboratory that pertain to the contribution of chromatin remodeling proteins with chromatin at sites of DNA double-strand breaks. We are particularly interested in the Polycomb repressive complex 1, which is a histone H2A E3 ubiquitin ligase and participates in both developmental gene silencing and DNA double-strand break repair. Evidence currently supports the hypothesis that the high expression of this complex in stem cells and cancer stem cells increases the resistance of cancer stem cells to DNA damage-inducing therapies.
Tom Hobman Name: Tom Hobman
Position/Title: Professor
Institution and affiliations: Professor, Canada Research Chair in RNA Viruses and Host Interactions, Associate Dean, Research Facilities
Areas of Research: Health, Infectious Diseases, RNA interference and RNA virus Host Interactions
Additional Information

Andrew Mason Name: Andrew Mason
Position/Title: Professor, MBBS, MRCPI, Director of the Applied Genomics Centre, Co-Director Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR)
Institution and affiliations: Division of Gastroenterology, Department of Medicine / Applied Genomics Centre
Areas of Research: Health, Virology, Anti-retroviral Therapy and Viral Discovery
Additional Information

David M. Olson Name: David M. Olson
Position/Title: Professor, FRCOG
Institution and affiliations: Obstetrics and Gynecology, Pediatrics and Physiology
Areas of Research: Health, Perinatal health, and Allostatic load and preterm delivery; inflammatory mediators of preterm birth
Additional Information

Lynne-Marie Postovit Name: Lynne-Marie Postovit
Position/Title: Associate Professor, Sawin-Baldwin Chair in Ovarian Cancer & Dr. Anthony Noujaim Legacy Oncology Chair, Alberta Innovates Health Solutions Translational Health Chair in Cancer
Institution and affiliations: Experimental Oncology, Department of Oncology
Areas of Research: Health, Cancer, Microenvironment as an epigenetic regulator of Cancer Progression & Epigenetics in Human Pluripotent Stem Cell
Additional Information
Luis Schang Name: Luis Schang
Position/Title: Professor
Institution and affiliations: Department of Biochemistry, Faculty of Medicine & Dentistry / Li Ka Shing Institute of Virology
Areas of Research: Health, Virology, Viral Infection, Replication, or Pathogenesis
Additional Information

Michael Schultz Name: Michael Schultz
Position/Title: Professor
Institution and affiliations: Department of Biochemistry, Faculty of Medicine & Dentistry
Areas of Research: Health, Biochemistry, Epigenetic Mechanisms Regulating Genome Structure
Additional Information

Alan Underhill Name: Alan Underhill
Position/Title: Associate Professor, Mary Johnston Chair in Melanoma Research
Institution and affiliations: Experimental Oncology, Department of Oncology / Cross Cancer Institute
Areas of Research: Health, Cancer, Epigenetic Control in Cell Differentiation and Cancer
Additional Information
Gene Regulation in Development and Disease

The Underhill laboratory is interested in understanding how aberrant gene regulation contributes to birth defects and cancer through the study of two overlapping model systems. In the first case, we study the essential developmental transcription factor Pax3. Mutations in the PAX3 gene occur in the mouse mutant Splotch and human Waardenburg syndrome, and are characterized by neural tube defects, sensorineural deafness and pigmentary disturbances, as well as craniofacial defects and reductions in limb musculature. From a gain-of-function standpoint, PAX3 is involved in a causative translocation in alveolar rhabdomyosarcoma and is often deregulated in neural crest-derived cancers, most notably in melanoma. As a result, the characterization of Pax3 provides an opportunity to understand the role of PAX genes in human congenital disease and lineage restricted malignancy, as well as their regulation of cellular differentiation. We are currently studying how Pax3 functions in the context of the nucleus using a number of cytological and molecular techniques. Our second project involves characterizing histone modifications during development and in cancer. The four core histones (H2A, H2B, H3, and H4) undergo a range of post-translational modifications—amongst these, we are most interested in methylation of histone H4. This modification is dynamic during cell differentiation and its accumulation is frequently disrupted in malignancy. We are currently using embryonic muscle development as a model to understand how histone H4 methylation regulates the balance between cell division and differentiation.

Technologies used: Molecular biology, Genetics, Biochemistry, Cell Imaging, and Bioinformatics
Benjamin Willing Name: Benjamin Willing
Position/Title: Assistant Professor / Canada Research Chair in Microbiology of Nutrigenomics
Institution and affiliations: Agricultural, Food & Nutritional Science
Areas of Research: Health, Diabetes, Microbiology of Nutrigenomics
Additional Information
A diverse and abundant population of symbiotic microbes colonizes the mammalian gastrointestinal tract. Imbalances in this microbial community contribute to many diseases including asthma, diabetes, obesity, inflammatory bowel disease, and increased susceptibility to infection. These microbes shape how the host responds to changes in diet, yet we know relatively little about how different members of the microbiota contribute to this process. The objectives of my research are to understand how different members of the resident flora contribute to the metabolism of the diet and how this process contributes to microbial regulation of host physiology. In my research I manipulate microbial community structure using antibiotic and gnotobiotic (germ-free) animal models and use tissue culture, metabolomics and transcriptomics to study this complex system. By understanding the mechanisms through which microbes regulate host physiology and which bacteria are responsible will allow us to set targets for how we should alter the microbiota to promote health in livestock and humans.

Richard Wozniak Name: Richard Wozniak
Position/Title: Professor, Howard Hughes Medical Institute International Research Scholar
Institution and affiliations: Department of Cell Biology
Areas of Research: Health, Aging, and Function and Regulation of Nuclear Pore Complexes
Additional Information
Summary of Research Plan

In all eukaryotic cells, genes are housed in the nucleus. The nucleus segregates the genome away from the surrounding cytoplasm using a double membrane barrier termed the nuclear envelope (NE). For most macromolecules to cross the NE, they require the appropriate transport signals. These signals, through interactions with transport proteins, allow passage across the NE through massive channels termed nuclear pore complexes (NPCs). By regulating what enters or leaves the nucleus, NPCs play a central role in controlling gene expression. In addition, recent evidence from our laboratory and others suggests that NPCs regulate gene expression by directly modulating chromatin structure and the spatial organization of the genome. As these critical functions of NPCs would imply, mutations in components of NPCs are deleterious, and they have been linked to a variety of diseases including Alzheimer's disease, heart disease, and cancer. Moreover, viruses often target NPCs during infection to support their replication.

Over the years, we have made important discoveries describing the structure and function of NPCs in yeast and mammalian cells, and, in the process, we have established collaborations with leading national and international scientists. Building on our previous accomplishments and a strong collaborative network, it is our goal to use state-of-the-art technologies available in yeast and human cell culture systems to examine the role of NPCs as architects of chromatin structure and epigenetic regulators of gene expression. We are using this information to study how altering or compromising NPC function contributes to disease states arising from fungal and viral infections.

Our ongoing research program consists of two general areas of focus. First, we will use yeast and human cell model systems to identify and characterize the molecular interface between NPCs and chromatin. The long-term goals of these studies are to define the contributions of NPCs to the assembly and modulation of chromatin structure, and to define the function of NPCs in the transmission of the epigenetic features to daughter cells. An important byproduct of this research will be an understanding of the role of NPCs in regulating the expression of virulence genes in pathogenic yeast, and the potential to exploit this mechanistic information for the purpose of developing novel approaches to treating fungal diseases.

Finally, we have developed a collaborative network to explore the role of NPC proteins in viral infections. In the initial stages of this work, we showed that infection with plus-strand RNA viruses (including hepatitis A and C, Dengue, and Zika) causes redistribution of several NPC proteins to cytoplasmic membranes where we propose they contribute to the compartmentalization of viral replication. We also hypothesize that this redistribution of NPC proteins alters their canonical functions, including their ability to regulate host cell gene expression. Through an investigation of interactions between viral and NPC proteins, we predict this work will identify NPC proteins commonly targeted by plus-strand RNA viruses, offering the potential for the development of inhibitors with broad-spectrum antiviral activity.

University of Calgary

Gwyn Bebb Name: Gwyn Bebb
Position/Title: Associate Professor, Director Clinical Trials Unit, Director Glans Look Lung Cancer Database
Institution and affiliations: Department of Medical Oncology, Faculty of Medicine, University of Calgary / Southern Alberta Cancer Research Institute
Areas of Research: Health, Cancer, Markers of genomic instability in guiding cancer treatment
Additional Information
Markers of genomic instability in guiding cancer treatment Lung cancer treatment has been a focus of the Bebb lab. In particular, how to inhibit signaling pathways that can affect cancer migration. These studies are conducted using animal models to test this anti-lung cancer approach in vivo. The Bebb Lab is also working to improve the effectiveness of cytotoxic chemotherapy treatments for mantel cell lymphoma and non-small cell lung cancer by inhibiting bcl-2 regulatory protein with interfering RNAs. Lastly, the role of reovirus in the treatment of MCL and lung cancer is being investigated.
Jennifer Cobb Name: Jennifer Cobb
Position/Title: Assistant Professor
Institution and affiliations: Biochemistry & Molecular Biology / Southern Alberta Cancer Research Institute (SACRI)
Areas of Research: Health, Cancer, Genome Instability and DNA Breaks
Additional Information

Jason de Koning Name: Jason de Koning
Position/Title: Assistant Professor
Institution and affiliations: Departments of Biochemistry & Molecular Biology, and Medical Genetics Research Institute
Areas of Research: Informatics, Computational Genomics, and Comparative, Statistical, and Personal Genomics
Additional Information
Michael Esser Name: Michael Esser
Position/Title: Assistant Professor
Institution and affiliations: Alberta Children's Hospital Department of Paediatrics
Areas of Research: Health, Neurosciences, Paediatric Brain Injury
Additional Information
Gaining a better understanding of the factors affecting selective cellular vulnerability to injury with the goal of applying this information to the development of novel treatment strategies. Using a variety of techniques, the effect of the injury at the cellular, tissue and systems level will be examined, as well as the factors that affect outcome including premorbid genetic susceptibility and alterations of fetal neurodevelopmental programming. The goal is to intervene on selected targets in an effort to alter the outcome and promote development of novel therapeutics.

Other areas of research:

Through the established paediatric neurology brain injury clinical program at ACH, developing a translational program linking the bedside and the bench.
Don Fujita Name: Don Fujita
Position/Title: Professor
Institution and affiliations: Departments of Biochemistry & Molecular Biology, University of Calgary / Southern Alberta Cancer Research Institute (SACRI) /Scientific Staff, Tom Baker Cancer Centre
Areas of Research: Health, Cancer, RNAi Interference of Oncogenes
Additional Information
  • Studies on the regulation and functions of tyrosine kinases, with particular emphasis on the human c-src gene product cSrc. cSrc is a master cellular control protein that is involved in cell proliferation, differentiation, motility, angiogenesis and other functions. When its kinase activity is aberrantly activated, cSrc is capable of causing the development and/or progression of various cancers, such as colon and breast cancer. We have recently shown that an important function of Src involves the targeting and phosphorylation of important tumor suppressor proteins such as pVHL (von Hippel-Lindau), and ING1b (with K. Riabowol’s lab), resulting in their destabilization and functional impairment.
  • Development and use of strategies to inhibit tumor growth and metastases utilizing RNA interference (RNAi) with specific siRNAs or combinations of siRNAs that knock-down levels of important cancer causing proteins. Currently, tumor penetrating peptides (TPPs) and TPP-nanoparticle delivery systems are being designed and evaluated for their ability to block breast cancer tumor growth and metastasis in mouse model systems.
Aaron Goodarzi Name: Aaron Goodarzi
Position/Title: Assistant Professor
Institution and affiliations: Robson DNA Science Centre, Southern Alberta Cancer Research Institute / Department of Biochemistry & Molecular Biology and Department of Oncology at the Cumming School of Medicine
Areas of Research: Health, Cancer, Genome Instability
Additional Information
From the moment of our conception, our DNA is subject to damage, the most serious form being a break in both strands of the DNA double helix. Unless these breaks are resealed correctly, whole segments of our genome can be lost or irrevocably mutated to fuel a self-propagating process of volatility that underlies cancer formation, radiation poisoning and/or premature cellular aging.

Our research focuses on slow-repairing DNA double strand breaks, particularly those induced within densely compacted heterochromatin or by high linear energy transfer ionizing radiation such as alpha particles emitted by radon gas. We are especially curious about DNA double-strand break repair processes involving nucleosome remodeling enzymes. Discoveries in these areas are improving our knowledge of cancer formation, human ageing and radiation protection.

Dr. Goodarzi is the Canada Research Chair for Genome Damage and Instability Disease and is both the Education Lead and Microscopy Lead for the University of Calgary’s Arnie Charbonneau Cancer Institute. He obtained his PhD from University of Calgary in 2005 and trained as a post doctoral scholar at the Genome Damage and Stability Centre at the University of Sussex (UK) until 2010. In 2011, he opened his own laboratory at the University of Calgary’s Cumming School of Medicine. In 2015, he was named one of Calgary's Top 40 Under 40 for achievements in science and education and, in 2016, was named a "Peak Scholar" by University of Calgary President Elizabeth Cannon for his efforts in knowledge engagement in the area of the health impact of radon gas inhalation.
Steven Greenway Name: Steven Greenway
Position/Title: Assistant Professor
Institution and affiliations: Pediatric Cardiologist, Alberta Children’s Hospital Assistant Professor, Departments of Pediatrics, Cardiac Sciences and Biochemistry & Molecular Biology Full member of Alberta Children’s Hospital Research Institute and Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary
Areas of Research: Health, Cardiology, Diagnostic genomics
Additional Information
The application of next-generation sequencing (NGS) to congenital heart disease (CHD) and paediatric cardiomyopathy. By using NGS to sequence the exomes and/or genomes of children with these conditions, Dr. Greenway hopes to discover novel disease genes and increase our understanding of the genetics of CHD and cardiomyopathy. These studies may provide novel biomarkers, insight into underlying pathologic processes or help explain the differences between children and adults seen clinically.
Dr. Greenway is also interested in the use of genomic diagnostics in transplantation.

Current and Past Funding:
  • Enduring Hearts
  • Children’s Cardiomyopathy Foundation
  • Alberta Children’s Hospital Foundation
  • Department of Pediatrics
  • Libin Cardiovascular Institute of Alberta
  • Cumming School of Medicine

Benedikt Hallgrimsson Name: Benedikt Hallgrimsson
Position/Title: Professor, Head of the Department of Cell Biology & Anatomy
Institution and affiliations: Department of Cell Biology & Anatomy
Areas of Research: Health, Development, The Developmental Genetic Basis for Phenotypic Variation
Additional Information
Research Summary:
  • The developmental genetic basis for phenotypic variation. Despite the tremendous progress made in recent years towards understanding fundamental developmental mechanisms, we know very little about the genetic or developmental causes of phenotypic variation within species or among related species. This is a central area for evolutionary biology as phenotypic variation is the raw material on which evolution acts. It is also an area that has important implications for understanding etiologically complex malformations such as cleft lip and palate. Such malformations occur at the extremes of multifactorial phenotypic distributions and must be understood within the same theoretical framework as other aspects of variation.
  • The developmental-genetic basis for variation in canalization, morphological integration, and developmental stability. How developmental systems modulate the translation of genetic into phenotypic variation is a fundamental question in current evolutionary developmental biology. It is clear that most genetic variation is cryptic, as evidence by the ubiquity of recessivity. It is also clear that the expression of genetic variation is dependent on genetic background and that pleiotropy is the norm. At the phenotypic level, the complexities of the genetic to phenotypic translation can be grouped into three phenomena. Canalization and developmental stability (DS) refer to the tendency of developmental processes to follow particular trajectories despite external or internal perturbation. Canalization is the tendency for development of a specific genotype to follow the same trajectory under different conditions (different environment or different genetic backgrounds) while DS is the tendency for development of a specific genotype to follow the same trajectory under the same conditions. Morphological integration refers to the tendency for structures to show correlated variation because they are affected by shared developmental processes. All three phenomena are emergent properties of developmental systems that complicate the translation of genetic to phenotypic variation.
Randal N Johnston Name: Randal N Johnston
Position/Title: Professor, Director of the Master of Biomedical Technology Program
Institution and affiliations: Departments of Biochemistry & Molecular Biology, Oncology / Tom Baker Cancer Centre / Southern Alberta Cancer Research Institute
Areas of Research: Health, Cancer, Oncolytic Virus Resistance and Genomic Evolution in Cancer
Additional Information

Claudia Klein Name: Claudia Klein
Position/Title: Assistant Professor. DACT, DECAR
Institution and affiliations: Faculty of Veterinary Medicine
Areas of Research: Agriculture, Livestock, Epigenetic Effects of Assisted Reproductive Techniques, Physiology of Early Equine Pregnancy
Additional Information
Current & Past funding
  • CFI – Canadian Foundation for Innovation
  • NSERC Discovery Grant
  • Zoetis Investment in Innovation Fund
Roman Krawetz Name: Roman Krawetz
Position/Title: Assistant Professor
Institution and affiliations: Departments of Surgery/Cell Biology & Anatomy
Areas of Research: Health, Chronic Disease, Stem cells in patients with osteoarthritis
Additional Information

Susan Lees-Miller Name: Susan Lees-Miller
Position/Title: Professor
Institution and affiliations: Departments of Biochemistry and Molecular Biology, Oncology and Biological Sciences / Southern Alberta Cancer Research Institute
Areas of Research: Health, Cancer, Detection of DNA Double Strand Breaks
Additional Information

Nicole Letourneau Name: Nicole Letourneau
Position/Title: Professor
Institution and affiliations: Professor, Norlien/Alberta Children’s Hospital Foundation Research Chair in Parent-Infant Mental Health
Areas of Research: Health, Development, and Parenting and child development
Additional Information

Kenneth D. Lukowiak Name: Kenneth D. Lukowiak
Position/Title: Professor
Institution and affiliations: Professor, Norlien/Alberta Children’s Hospital Foundation Research Chair in Parent-Infant Mental Health
Areas of Research: Health, Development, and Parenting and child development
Additional Information
The causal neuronal mechanisms of learning, memory formation and forgetting. We are especially interested in how stress alters memory formation; especially ecologically relevant stressors such as predator detection and crowding.
Aru Narendran Name: Aru Narendran
Position/Title: Assistant Professor
Institution and affiliations: Departments of Oncology, Paediatrics Alberta Children's Hospital / Hughes Children's Cancer Research Laboratories / Southern Alberta Cancer Foundation Institute (SACRI)
Areas of Research: Health, Cancer, Paediatric Oncology Therapeutics
Additional Information

Richard T. Pon Name: Richard T. Pon
Position/Title: Adjunct Professor, Director, ACHRI Genomics and UCDNA Services
Institution and affiliations: Department of Biochemistry & Molecular Biology/ Director, University Core DNA Services
Areas of Research: Informatics, Genomics, Whole genomic analysis through DNA sequencing technology;  synthesis of nucleic acids through organic chemistry DNA/RNA synthesis
Additional Information

Karl T Riabowol Name: Karl T Riabowol
Position/Title: Professor
Institution and affiliations: Arnie Charbonneau Cancer Institute, Alberta Children's Hospital Research Institute, Departments of Biochemistry & Molecular Biology and Oncology, Cumming School of Medicine and Tom Baker Cancer Institute, University of Calgary
Areas of Research: Health, Aging, Transcriptional Regulation in Cell Aging
Additional Information
Carol Schuurmans Name: Carol Schuurmans
Position/Title: Professor / Director Department of Neuroscience
Institution and affiliations: Department of Biochemistry & Molecular Biology / Department of Neuroscience
Areas of Research: Health, Neuroscience, Epigenetic Regulation of Cortical Development
Additional Information

Jacob Thundathil Name: Jacob Thundathil
Position/Title: Associate Professor
Institution and affiliations: Faculty of Veterinary Medicine
Areas of Research: Agriculture, Livestock, Regulation of Sperm Function
Additional Information
Dr. Thundathil’s research is focused on regulation of sperm function and sperm contributions to embryo development at an interdisciplinary level. In addition, he is interested in developing reproductive technologies for preserving endangered wildlife and technology enhanced learning in DVM program. His specific research projects are: 1) Morphologically abnormal bovine sperm: A model for the study of spermatogenesis, sperm function and sperm contributions to preimplantation embryo development (funded by NSERC-DG); 2) Na/K-ATPase as a fertility marker for beef cattle (funded by ALMA); 3) Development of reproductive technologies for genetic preservation; 4) Modulation of nutrition as a management tool for enhancing reproductive potential of dairy bulls (collaborative project with Dr. John Kastelic; supported through Eyes High initiative, U of C); 5) Testis-specific isoform of Angiotensin Converting Enzyme as a fertility marker in dairy bulls (NSERC-CRD); 6) Potential impacts of pre-natal nutrition and selection for residual feed intake (RFI) on bull reproductive development and fertility (collaborative project with Dr. Carolyn Fitzsimmons, U of A); and 7) Use of Virtual Animal Patient case simulations for teaching and assessing DVM courses. The most exciting aspect of Dr. Thundathil's research program is the availability of a wide spectrum of expertise, facilities, and collaborators (within and external to U of C), which attracts trainees with various backgrounds (basic science and DVM) and research interests (basic science, applied and clinical research).

Important research contributions:

  • Identified several functional markers for bull fertility (J Proteomics 2013;82:64-80; Theriogenology 2012; 77:940-951).
  • Reported for the first time that elevated testicular temperature modulates expression patterns of a cohort of sperm proteins in Holstein bulls (Mol Reprod Dev 2009;76:109-118).
  • Demonstrated that Na/K-ATPase regulates bovine sperm capacitation through kinases and redistribution of its testis-specific isoform (Mol Reprod Dev 2010;77:136-148).
  • Validated plains bison as a model for developing reproductive technologies for wood bison (Theriogenology 2011; 75:1360-1370).
  • First time report on in vitro production of embryos from wood bison (Theriogenology 2007;68:93-99).
  • Developed and tested effectiveness of computer-based case simulations for DVM teaching.
Edwin Wang Name: Edwin Wang
Position/Title: AIHS Chair Professor in Cancer Genomics/Informatics, University of Calgary, Cumming School of Medicine
Institution and affiliations: University of Calgary Cumming School of Medicine Center for Health Genomics and Informatics Department of Biochemistry and Molecular Biology Department of Medical Genetics Department of Oncology Alberta Children's Hospital Research Institute Arnie Charbonneau Cancer Research Institute O'Brien Institute of Public Health
Areas of Research:
Additional Information
Wang Lab includes a computational lab and an experimental lab. Traditionally Wang Lab was mainly working on computational systems biology. Since 2016, Wang Lab has shifted toward conducting both computational and experimental systems biology. The computational work includes:
  • big medical data analysis
  • machine learning and deep learning
  • predictive model construction based on genomic data of diseases including cancer
  • integrating omic and electronic medical records (EMR) data (including imaging data) to develop and validate omics-EMR-based biomarkers for predicting of the risk, prognosis and drug response of complex diseases.
We are developing novel algorithms for modeling of molecular networks and precision health, and also developing new concepts for data analysis toward interpreting data, generating, prioritizing and testing new hypotheses.

University of Lethbridge

Robbin L Gibb Name: Robbin L Gibb
Position/Title: Professor
Institution and affiliations: Centre for Behavioural Neuroscience, Department of Neuroscience
Areas of Research: Health, Neuroscience, and How pre- and perinatal experience shaping brain Development.
Additional Information
Dr. Gibb studies changes in brain plasticity mediated by prenatal or early postnatal events. She is particularly interested in how to enhance recovery following early brain injury. Dr. Gibb worked with the National Judicial Institute doing presentations on brain development to inform family court, superior court, and supreme court justices. These talks are aimed at helping the judiciary make judgements in the best interest of the child.
Roy Golsteyn Name: Roy Golsteyn
Position/Title: Associate Professor, Director of the Cancer Cell Laboratory
Institution and affiliations: Department of Biological Sciences / Associate member, Southern Alberta Cancer Research Institute (SACRI)
Areas of Research: Health, Cancer, and Drug Discovery in Biochemical and Epigenetic targets
Additional Information
Research Interests
My laboratory focuses on human cell biology to answer questions about cancer mechanisms and discovery new cancer drugs. We use cell-based assays to investigate biochemical and epigenetic pathways that cause cancer cells to be different from normal cells. We have expertise in the cellular process of Checkpoint Adaptation, or mitosis with damaged DNA. Recently, we have developed the Prairie to Pharmacy Program in which we design phenotypic assays find new anti-cancer chemicals against biochemical and epigenetic targets. Our research interests include:
•Cancer Cell Biology
•Natural Product Inhibitors
•Mitosis
•Protein kinases
•Cell Cycle

Current & Past funding (2015-2017)
  • NSERC Discovery Grants Investigation of mitosis in human cells using novel chemical inhibitors 2017-2022
  • Canadian Foundation for Innovation Infrastructure Operating Funds - Prairie to Pharmacy2016-2022
  • University of Lethbridge GRS Funding Research Service Next Level - Prairie to Pharmacy Program2016-2018
  • Alberta Cancer Foundation Transformative Program 2014 (Leader Dr. Michael Weinfeld U of Alberta) Novel Therapeutic Strategies for Unresectable Lung Cancer Based on Targeting DNA Repair2015-2018
  • Private DonationFunding donated directly to the Cancer Cell Laboratory at the University of LethbridgePrairie to Pharmacy Project: Foundations2015-2018
  • Alberta Innovates Health SolutionsSustainability ProgramPreclinical investigation of PP-0062016-2017
  • University of LethbridgeChinook Summer StudentshipInvestigating prairie plant extracts for novel activities against human cancer cellsSummer 2017
  • University of LethbridgeAgility Research and Innovation Grants in AgricultureTesting the cultivation of Canadian prairie plants with anti-cancer activity for commercial production2015-2017
  • NSERCUSRA Summer studentshipInvestigation of previously untested prairie plant species for secondary metabolites that have bioactivitiesSummer 2016
  • Alberta Innovation and Advanced EducationResearch Capacity ProgramPrairie to Pharmacy Project: Infrastructure2015-2017
  • Canadian Foundation for InnovationJohn R. Evans Leaders Fund (JELF)Prairie to Pharmacy Project: Infrastructure2015-2017
  • University of LethbridgeUniversity of Lethbridge Research FundThe Prairie to Pharmacy Program: Chemicals2015-2016
  • Regional Innovation Network of Southern Alberta (RINSA)Patent SupportProduction of high value chemicals from plants2015
Bryan Kolb Name: Bryan Kolb
Position/Title: Professor, Director of CIFAR’s Child & Brain Development program, Fellow of the Royal Society of Canada
Institution and affiliations: Canadian Centre for Behavioural Neuroscience, Department of Psychology & Neuroscience / CIFAR Child & Brain Development program
Areas of Research: Health, Neuroscience, Impact of Experience and Environmental Factors on Brain Development
Additional Information

Ute Kothe Name: Ute Kothe
Position/Title: Associate Professor
Institution and affiliations: Chemistry & Biochemistry / RNA Research and Training Institute
Areas of Research: Biochemistry, RNA, Ribosome Biogenesis, and RNA Modification, RNA-protein Interactions
Additional Information

Igor Kovalchuk Name: Igor Kovalchuk
Position/Title: Professor
Institution and affiliations: Plant biotechnology laboratory, Department of Biological Sciences
Areas of Research: Epigenetics, Plants, and Plant Stress Response and Plant Biotechnology
Additional Information

Olga Kovalchuk Name: Olga Kovalchuk
Position/Title: Professor / Alberta Innovates Health Solutions Translational Health Chair: RNA in Health and Disease
Institution and affiliations: Department of Biological Sciences / Southern Alberta Cancer Research Institute
Areas of Research: Health, Cancer, Epigenetics in Carcinogenesis and Cancer Treatment Responses
Additional Information

Robert J. McDonald Name: Robert J. McDonald
Position/Title: Associate Professor, Canada Research Chair
Institution and affiliations: Centre for Behavioural Neuroscience, Department of Psychology & Neuroscience
Areas of Research: Health,Neurosciences, and Learning and Memory
Additional Information
Bruce McNaughton Name: Bruce McNaughton
Position/Title: Professor
Institution and affiliations: Centre for Behavioural Neuroscience, Department of Psychology & Neuroscience
Areas of Research: Health, Neurosciences, and Learning and Memory
Additional Information
Gerlinde Metz Name: Gerlinde Metz
Position/Title: Professor, Canadian Centre for Behavioural Neuroscience, University of Lethbridge
Institution and affiliations: Tier 1 Board of Governors Research Chair Adjunct Professor, Department of Obstetrics and Gynecology, University of Alberta
Areas of Research: Health, Neurosciences, and Impact of Environment and Experience on Behavior and Brain Plasticity
Additional Information
The research program of Dr. Gerlinde Metz focuses on the influence of experience and environment on behaviour and brain plasticity. Her work showed that stress affects motor system function, risk of Parkinson’s disease and recovery from stroke. More recently, her laboratory has developed unique models to explore transgenerational inheritance of stress responses. Through transgenerational programming, experience in parents, grandparents and beyond can influence health and disease from early development to old age.

Trainees in the Lab:

2008 - presentErin Falkenberg (Postgraduate Research Technician)
2009 - present Jamshid Faraji (Research Associate)
2010 - present Nasrin Soltanpour (Postgraduate Research Technician)
2014 - present Mirela Ambeskovic (PhD), NSERC CGS-M Scholar
2016 - present Zachary Wanner (MSc), NSERC CGS-M Awardee
2016 - present Dennis Bettenson (MSc6)
2016 - present Teddi Reynolds (MSc)
2017 - present Hannah Scott (MSc)
2017 - present Tanzi Hoover (PhD)
2017 - present Janet Poplawski (MSc)
2017 - present Nayara Lopez (PhD, co-supervised with David Olson, U Alberta)

Trushar Patel Name: Trushar Patel
Position/Title: Assistant Professor, Laboratory of Medicinal Biophysics, Alberta RNA Research and Training Institute, University of Lethbridge
Institution and affiliations: Co-Director, DiscoveryLab, University of Alberta Assistant Professor (Adjunct), Dept. of Microbiology, Immunology & Infectious Diseases, University of Calgary
Areas of Research:
Additional Information
Dr. Patel established a Medicinal Biophysics Laboratory as part of Alberta RNA Research and Training Institute at the University of Lethbridge. His current research is focused on studying multi-domain proteins, RNA-protein and protein-protein complexes that affect various cellular processes and diseases, especially the role of focal adhesion proteins in prostate and breast cancer. He is also investigating host interacting partners that aid replication of viruses belonging to Flavivirus genus as well as of hepatitis B virus. His background working with molecules from polysaccharides to nucleic acids and experience in techniques from cell biology to structure biology allows him to connect dots from genes to function. Such information can lead to the development of novel inhibitors that interfere with host-viral component interactions and therefore inhibit viral replication.
Dr. Patel is a co-Director with the DiscoveryLab (the University of Alberta) which supports collaborative efforts from researchers with a wide range of background to discover and develop novel therapeutic agents. In addition, he is serving as an Assistant Professor (adjunct) at the Cumming School of Medicine, University of Calgary.

Grants applied for:

April 2018 -  March 2020
Principal Supervisor, Postdoctoral fellowship grant for Dr. Stephenson-Meier
Towards better understanding of the critical host protein, DDX3-HCV RNA interactions
Funding Source: Canadian Network on Hepatitis C
Amount: $104,400

April 2018  - March 2021
Principal Supervisor, Postdoctoral fellowship grant for Dr. Stephenson-Meier
Attacking the culprit behind hepatitis B virus persistence
Funding Source: Canadian Institutes of Health Research
Amount: $161,000

Jan 2018 - Dec 2022
Principal Applicant, Infrastructure Grant
Interaction Studies of Purified Biomolecules
Funding Source: Alberta Economic Development and Trade Research Capacity Program
Amount: $137,383

Apr 2018 - Mar 2020
Principal Applicant, Infrastructure Grant
Acquisition of a Biomolecular Imager at the University of Lethbridge
Funding Source: Natural Sciences and Engineering Research Council of Canada
Amount: $150,000

Grants currently being held:

Jan 2018 - Dec 2022
Principal Applicant, Infrastructure Grant
Interaction Studies of Purified Biomolecules
Funding Source: Canada Foundation for Innovation
Amount: $137,383

Apr 2018 - Mar 2019
Principal Applicant, Infrastructure Access
Biomolecular Interactions in Health and Environment
Funding Source: Diamond Light Source Ltd (Beam time Allocation Group)
Amount: $379,042

Nov 2017 Oct 2022
Sole Applicant, Research Chair, Canada Research Chair (CRC)
Targeting the Host Proteins for an Antiviral Therapy
Funding Source: Canadian Institutes of Health Research
Amount: $500,000

Oct 2017 - Sep 2018
Principal Applicant, Infrastructure Access
Acquisition of a Biomolecular Imager at the University of Lethbridge
Funding Source: Vice-President (Research) Strategic Opportunities Fund
Amount: $20,000

Oct 2017 - Sep 2018 Principal Applicant, Infrastructure Grant
Studying Host-viral Interactions in Solution
Funding Source: Instruct Integrating Biology
Amount: $18,959

June 2017
Sole Applicant, Travel Grant, University of Lethbridge Faculty Travel Fund
Funding Source: University of Lethbridge
Amount: $1,200

Apr 2017 - Mar 2018 Principal Applicant, Infrastructure Access
Biomolecular Interactions in Health and Environment
Funding Source: Diamond Light Source Ltd (Beam time Allocation Group)
Amount: $379,042

Apr 2017 - Mar 2022
Sole Applicant, Operating Grant
Identifying Structural Features of Viral RNA Recognized by Host Helicases
Funding Source: Natural Sciences and Engineering Research Council of Canada: Discovery Grant
Amount: $155,000

Apr 2017 - Mar 2019 Co-applicant, Operating Grant
Development of DDX3X as a Therapeutic Tool for Hepatitis B Virus (HBV) and Hepatitis Delta Virus (HDV) Infections
Other Investigators: Dr. Carla S. Coffin
Funding Source: Calgary Clinical Research Fund: Seed fund,
Amount: $10,000

Nov 2016 - Nov 2017
Sole Applicant, Grant, Seed Corn Funding
Funding Source: Canada-UK Foundation: Seed Corn Funding,
Amount: $3,300

Sep 2016 - Jun 2020
Sole Applicant, Operating Grant, University of Lethbridge Startup Fund Sep
Funding Source: University of Lethbridge: Start-up fund, Total: $237,000

Robert J Sutherland Name: Robert J Sutherland
Position/Title: Professor, Director Centre for Behavioural Neuroscience, Chair of the Department of Neuroscience
Institution and affiliations: Centre for Behavioural Neuroscience
Areas of Research: Health, Neuroscience, Memory and Learning
Additional Information
Hans-Joachim Wieden Name: Hans-Joachim Wieden
Position/Title: Associate Professor / iCORE Strategic Chair in RNA Bioengineering / Director, Alberta RNA Research and Training Institute (ARRTI)
Institution and affiliations: Department of Chemistry and Biochemistry
Areas of Research: Biochemisty, Noncoding RNA & Systems and Biomolecular Design, Biophysics, Molecular Dynamics Simulations, Structure function, & Kinetics
Additional Information

Our Partners

Alberta Government Genome Alberta University of Calgary University of Lethbridge University of Alberta